Epilepsy is a common chronic neurological disorder that affects people of all ages. It is caused by abnormal electrical activity in the brain. A person with epilepsy experiences a sudden episode of seizures, which may include sensory disturbance, unconsciousness, and repetitive muscle jerking (Wlodarczyk et al., 2012). The treatment is the daily intake of antiepileptic drugs (AEDs) regimen. More than 90% of pregnancies proceeds without complications in women with epilepsy, although there is the slight increase in adverse effect outcome that is found, it is advised that women with epilepsy should do careful planning of pregnancy, pregnancy counseling and delivery management (Viinikainen et al., 2006). Complications associated with epilepsy during pregnancy include prolonged labor, vaginal bleeding, surgical delivery, preeclampsia (which occurs in 5-6% of all pregnancies), and frequency of seizures (Viinikainen et al., 2006). There are many interactions between epilepsy and pregnancy, but the main concern is the effect of AEDs on t
he development of the fetus. The maternal is advised to take the AEDs treatment to prevent the detrimental effect of epileptic seizures on themselves and the fetus (Meador et al., 2008). The problem with outcome exposure of these AEDs is that they increase the risk of congenital malformation, fetal death, feeding difficulties, neonatal hemorrhage, low birth weight neurocognitive development, and childhood epilepsy on the child (Viinikainen et al., 2006), these effects make it difficult to manage epilepsy during pregnancy. What also needs to be considered is the risk that is linked with uncontrolled seizures on the maternal and the fetus, the effect of pregnancy on the controlled seizure, the potential development of toxicity of the epilepsy drugs treatment (Battino and Tomson, 2007). The aim of this literature review is to discuss the management of epilepsy during pregnancy with an emphasis on the teratogenic effect of antiepileptic drugs as well as the control of seizures during pregnancy, and the effect of pregnancy on the AEDs.