Alzheimers disease is the most common form of dementia, this disease is the fourth leading cause of death in industrialized nations, preceded by cardiovascular disease. Neurodegenerative disease (ND) is an umbrella term for a group of primary diseases of neuron with the defining feature of a progressive loss of functioning neurons, mainly in the cortex and hippocampus, during the process of learning and memory formation brain undergoes a physical and chemical change which called as synaptic plasticity, its shows contribution of various signal transfusion pathway induction of gene expression which result formation of new synapse between nerve cell, this process undergoes remodelling with time the memory of a new experience can we divided by three types- namely short term, long term memory. The process of memory formation involves the binding neurotransmitter to the receptor which triggers the cascade oh molecular events including action of CREB and PKc pathways, resulting in the formation of new protein receptor and some structural proteins, the synaptic connection between two repeatedly communicating neurons which ultimately result developed long term memory. Memory can be classified into declarative and non-declarative, declarative memory affords and capacity for cognizant recollection about fact and event, in
declarative memory a heterogeneous collection nonconscious ability in include learning of skills and way of life, in these cases behavioral change, but without according access any memory content, and different kind of memory are supported by different brain system. This disease has provided significant path physiology, it affects all ethnic groups and occurs slightly more in female than males. Disease according to age like brain disorder in create symptoms such as confusion and memory loss and sometime after converted yet normal age in personality and behaviour changed and awareness decision and in creative problem among friends and family members in complete loss, form mental works functions because this disease related to a mutation in most cases of Alzheimer’s disease has mostly with 65 years old people. ApolipoEprotein is major genetic risk factor play the role of increased problem in Alzheimers disease, apolipoprotein is a cholesterol carrier for lipid transfer repair damage in brain, cause mutation responsible for amyloid precursor protein apolipoprotein located in chromosome 19 and encodes299 amino acid, extracellular plaques of insoluble beta-amyloid peptide and neurofibrillary tangles remaining hyperphosphorylated tou protein in neuronal cytoplasm is remarkable path physiological cause patients brain.